Anomaly may refer to the following:
- Anomaly (artifact) – (Extraterrestrial artifact linked to the Darkness, housed on the Moon)
- Anomaly (Splicer) – (Eliksni Splicer who helped to erase all knowledge of Eido from the Vex Network)
- Anomaly (Vesper) — (A portal of unknown origin which serves as the focal point of the Vesper's Host Dungeon)
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